One of the major problems in sweetpotato production is the damage caused by nematodes. The nematodes that limit sweetpotato production are sweetpotato root-knot and rot-knot nematode. The intergrated methods are used to control the disease in sweetpotato production. Among them, the best efficient and economical way to controlling the disease is breeding of resistant varieties. The research progress of sweetpotato root-knot and rot-knot nematode on resistant germplasm screening, resistant mechanism, inheritance and breeding of resistance are reviewed in this paper. The perspective of breeding for resistance to nematodes has also been prospected.