Rye is an important genetic resource for wheat improvement which contains a lot of resistant genes, Transferring the rye resistant genes into wheat is always an important work for wheat breeding. This article reviewed the advance researches about the location and marker, and the application of germplasm with rye resistance genes, the application value of rye resistance genes in wheat breeding is assessed, the problems of resistance effect and genes markers are raiseed and prospected, expected the rye beneficial genes could be used widely in wheat breeding.