Rice is one of the most important food crops in the world. Since this crop is moderately sensitive to salt stress, land salinization is therefore a factor that restricts the increase of global rice production. At present, most studies focus on the salt tolerance of rice at the seedling stage, whereas identification of salt-tolerant phenotypes during the reproductive growth period of rice is rarely conducted. Breeding for new varieties showing salt-tolerant in lifecycle and its application is one of the optimal ways to improve saline soil. In recent years, a large number of salt-tolerant QTLs in rice have been molecularly identified, and significant progress has been made in breeding of new varieties showing salt tolerant. This article reviews the latest research progress in genomics, epigenetics, proteomics and metabolomics on salt tolerance, and provides a reference for exploring the molecular mechanism of salt tolerance and breeding for salt-tolerant varieties in rice.