Frogeye leaf spot is a global soybean disease caused by Cercospora sojina K. Hara， and its prevalence in major soybean production areas has resulted in significant yield losses. Cercospora sojina mutates rapidly and evolves multiple physiological races with different pathogenic specificity to overcome the resistance of cultivars. With the rapid development of molecular biotechnology recently， research focuses have been shifted in traditional breeding of resistance varieties to generate germplasm with broad-spectrum resistance， uncover its pathogenic mechanism and delimit resistance genes against soybean frogeye leaf spot. This article provides a systematic review on the identification of physiological races and pathogenicity of Cercospora sojina， inheritance of resistance and resistant breeding. We also explore the precise identification of disease phenotype， analysis of pathogenic mechanism， fine mapping of resistance gene， and resistant breeding， which provides reference for further research on soybean resistance to frogeye leaf spot.