Fusarium wilt is one of the most serious soil-borne diseases that affects common bean production. In the previous study, our research group identified PvFWR1 through a genome-wide association study and inferred that it might be related to resistance to common bean wilt through haplotype analysis. In this study, we conducted further research on PvFWR1. First, we cloned the PvFWR1 gene sequence from resistant material Tuheyaozidou and the susceptible material Longyundou No.3, and found that PvFWR1 is an intronless gene with a CDS length of 1104 bp and 367 amino acids, belonging to the LRR-RLKs protein family. Then, qRT-PCR showed that the expression level of PvFWR1 in the root tissue of resistant material was 2.1 times that of the susceptible material, and the expression level in the root tissue of the infected plants was significantly higher after inoculation with the pathogen. Finally, we used VIGS technology to silence PvFWR1 in the resistant material, and the resistance of the plants was weakened after inoculation with the pathogen. At the same time, we used the common bean hairy root transformation method to overexpress PvFWR1 in the susceptible material, and the resistance of the overexpression plants was significantly increased after inoculation with the pathogen. Based on these analyses, we concluded that PvFWR1 is a resistance gene against Fusarium wilt. The research results lay a foundation for elucidating the resistance mechanism of common bean wilt and the genetic breeding and utilization of PvFWR1.