Breeding disease-resistant rice varieties is the most economical and effective way to ensure rice yield and quality. Wild rice has retained many original traits that cultivated rice does not have due to its long-term survival in the natural environment. It contains abundant genetic resources and is an important gene pool for rice disease-resistant breeding. This paper introduces the characteristics and protection of three kinds of wild rice in China, and further describes the progress of screening of disease-resistant germplasm resources and identification and cloning of disease-resistant genes in wild rice. The distant hybridization, molecular marker-assisted selection (MAS), genetic engineering and gene editing breeding of wild rice were reviewed and analyzed. These contents hope to provide some reference for future research on disease resistance breeding of wild rice.