In order to study the effects of the wheat-Haynaldia villosa 6VS/6AL translocation chromosome on agronomic traits of common wheat, eleven derived advanced lines carrying 6VS/6AL translocation chromosome and their respective parents, three segregation advanced lines and five F2 population with and without the 6VS/6AL translocation chromosome were selected and analysed for agronomic traits. In general, there were no significant differences between 6VS/6AL lines and their recurrent parents in agronomic traits, including grain yield, spikelets, grains/spike and grain weight/spike. 6VS/6AL lines showed slightly but significantly higher thousand-kernel weight and spike length. Most 6VS/6AL derivatives showed higher plant height than their control parents. However, significant variation occurred for this trait among sister lines from the same cross, indicating that additional selection could lead to further improvements. It was concluded that the 6VS/6AL translocation can be used in wheat breeding programs as a donor of resistance to powdery mildew with no obvious undesirable effects on agronomic traits.