Thinopyrum intermedium, which is a perennial wheatgrass of Gramineae, is a wild relative species of common wheat. It generally develops stronger roots and shoots, larger spike and many flowers, and often represents good characters on biotic and abiotic stresses as well as higher protein content in the grains. Th. intermedium, as a target in breeding for perennial crops, has exhibited great potential in uses for grain and forage. In this paper, the achievements of direct domestication, distant hybridization with other crops, genomics-assisted breeding in Th. intermedium have been reviewed, and the future research focus and the breeding strategy have been prospected. This study can provide scientific basis for the improvement and utilization of Th. intermedium wild germplasm resources.