Glutathione peroxidase (GPX) plays an important role in response to salt stress in plant. Through the analysis on EST sequence of Thellungiella halophila, a novel gene exhibiting high homology with plant glutathione peroxidase was discovered and named as ThGPX6 (GenBank accession number: FJ357244)．ThGPX6 consists of 892 nucleotides，including a single 702bp opening reading frame which encodes a 234-amino acid peptide．Bioinformatics analysis showed that ThGPX6 had typical structures of GPX，such as catalysis region (NVASKCGLT), characteristic motif (ILAFPCNQF) and PHGPX special sequence (KWNF(S/T)KFL)．Quantitative real-time PCR analysis revealed that the gene expressed in shoot and root，and could be induced by NaCl in T.halophila．These results showed that the ThGPX6 played a crucial role under salt stress in T.halophila．