The application of the heterosis of rice subspecies increased the yield of rice dramatically, but the problem is still universal that hybrid sterility exists in subspecies as well as species of rice, and it hinders the utility of hybrid sterility of rice. In this paper, firstly, the cellular reason of hybrid sterility was elucidated in different aspects, then the genetic mechanism of hybrid sterility was discussed, and the delimitation and map-cloning of various different hybrid sterility genes were summarized, and the personal viewpoint of the author about how to overcome hybrid sterility and utilize hybrid heterosis was proposed in the end.