One-hundred twenty-one wheat germplasm accessions derived from distant hybridization were tested for salt-tolerance, in order to provide insight for salt-tolerant physiology, genetics and breeding in wheat. Based on D value, these materials were classified into five categories: highly salt-tolerant (five genotypes including P13, C1009, 1710, 1713 and 082-1, D value from 0.5877 to 0.6616); salt-tolerant (nine genotypes such as 1706, 081, 0819-1, PSR3628, TB1, D value ranged from 0.4222 to 0.5331); moderate salt-tolerant (41 genotypes such as 1707, 1805, TPF8, 1704, 1712, with a D value of 0.2684 to 0.3940); salt-sensitive (45 genotypes, with a D value of 0.1922 to 0.2640) ; highly salt-sensitive (21 genotypes, with a D value of 0.0504-0.1848). Especially, the D values of P13, 082-1, 081 and 082-2 lines derived from the cross Aegilops ventricosa × durum wheat ranged from 0.4231 to 0.6616, which showed high salt-tolerance or salt-tolerance. The average D values of the derivatives from einkorn wheat × Avena Fatua L．Var．Portugal, and T. timopheevii × Avena Fatua L. Var. Portugal were 0.4145 and 0.4106, which were significantly higher than that of common wheat accessions. The average D values of 8 progeny populations from wheat distant crosses were higher than that of common wheat. Finally, a few of new salt-tolerant germplasm accessions (i.e. P13, 1713, 082-1, 1706, 081) were identified.