It is important to uncover the genetic mechanism of lodging-resistance, and to explore the lodging-resistance genes and select the lodging resistant varieties of wheat, for ensuring food production safety in China. ‘Zhou 8425B’ is an important wheat backbone parent in Huang-Huai region of China with excellent agronomic characters, from which derived varieties with good lodging-resistance. This study explored the lodging-resistance associated loci in ‘Zhou8425B’ and 61 derived varieties, based on genome wide association analysis by 50 K SNP chip and eight lodging reaistance related traits. A total of 226 significantly associated SNP markers were detected, which were distributed at 42 loci on 21 chromosomes, accounting for 7.0%-18.8% of the phenotypic variations, respectively. Among them, 14 loci were consistent with the previously reported loci, and the other 28 loci were new. In addition, three candidate genes encoding E3 ubiquitin ligase, cellulose synthase and cell division protease were found at the significant sites. This study is of great significance for breeding lodging resistant wheat varieties.