This study analyzed the combining ability and heritability of the antioxidant active ingredients of red rice，which will provide theoretical reference for breeding of hybrid red rice rich in functional nutrients. By deployment of 6 three-line sterile lines and 8 red rice restorer lines to generate 48 hybrids of red rice following the incomplete diallel hybridization 6×8（NCII），the combining ability and genetic parameters of total phenols，total flavonoids，procyanidins and anthocyanins were analyzed. The results showed that there were genetic differences in the content of total phenols，total flavonoids，procyanidins and anthocyanins among the red rice hybrid combinations，which were affected by the additive effects of the sterile line parents and the non-additive effects between the combinations. The contents of total phenols，total flavonoids and proanthocyanidins were mainly controlled by the non-additive effects of genes，and the content of anthocyanins was affected by the interaction of additive and non-additive effects of genes. There was no direct correlation between the parental general combining ability（GCA）and the combined special combining ability（SCA），and there was no obvious correlation between the female parent with different brown rice color and the special combining ability of the red rice combination. The heritability analysis showed that the narrow-sense heritability of the four antioxidant active ingredients ranged from 12.99%-48.29%，which should be effective for selection in the middle and high generations. The contribution rate of the four antioxidant active ingredients of the sterile lines was greater than that of the restorer lines. The selection of female parents should be strengthened in the breeding of red rice hybrid rice. The female parents Yexiang A and Pinhong 1A were better in the breeding of red rice antioxidant active ingredients. Hybrid combinations Yexiang A×18Rr175 and Guang 8A×18Rr178 had high special combining ability effect value and great potential for production and application.