To analyze the yield potential of common wheat（Triticum aestivum L.）using high-grain weight germplasm resources in Ningxia，here we conducted the field trials for detecting grain weight under the ecological conditions of the Yellow River irrigation area，as well as marker-assisted analysis using four functional KASP markers TaGW2-6B，TaGASR，TaGS-D1 and TaCWI-4A. Four grain-related traits consisting of the thousand-kernel weight（TKW），kernel length（KL），kernel width（KW）and kernel thickness （KT）of 209 wheat germplasm resources were measured for 2 consecutive years. The results showed that wheat germplasm resources had abundant diversity on grain-related traits. The distribution ranges of TKW，KL，KW and KT values were 29.73-56.25 g，5.82-7.57 mm，2.87-3.83 mm and 2.74-3.55 mm，respectively. For TaGW2-6B，two haplotypes （Hap-6B-1 and Others）were detected，while the elite haplotype Hap-6B-1 accounted for 62.44%. For TaGASR two haplotypes（H1c and H1c/H1g）were detected，while haplotype H1c accounted for 93.10%. Two haplotypes Hap-4A-C and Hap-4A-T at TaCWI-4A-1523 were revealed，and the elite haplotype Hap-4A-C accounted for 76.41%. Two haplotypes TaGS-D1a and TaGS-D1b at the TaGS-D1 were revealed，and the elite haplotype TaGS-D1a accounted for 86.50%. The locus TaGW2-6B was found to be significantly correlated with TKW and extremely significantly correlated with KW and KT. TaGASR was found to be significantly correlated with TKW， KL and KW. TaCWI-4Awas found to be significantly correlated with TKW，KW and KT. Based on the genotyping results，seven haplotype combinations were revealed. The combination of Hap-6B-1+H1c+Hap-4A-C+TaGSD1a represented a significant positive effect on TKW，KW and KT，while the combination of Hap-4A-C+TaGSD1a represented a significant positive effect on KL. Taken together，three genes TaGW2-6B，TaGASR and TaCWI- 4Amight become elite makers on selection of the wheat grain weight under the ecological conditions of the Yellow River irrigation area in Ningxia. Out of 209 tested genotypes，14 high-grain weight genotypes（1000-kernel weight > 50 g）were identified，and nine of them have stacked elite haplotypes of four grain weight-related genes.