Since 1990s， scientists have mapped many quantitative trait loci through bi-parental populations such as NILs， DH， and IBD in plants through co-segregation between traits and markers. A set of important genes have been isolated by fine mapping， which are relating to biotic and abiotic stress resistance， environment adaptation， quality， and yield. These bring a lot of new biological knowledge. However， most of these genes were selected successfully in domestication and breeding.By 2010， with the establishment of reference genome sequences for most crops， genome re-sequencing has broken the limitation of the number of molecular markers， driving crop genetic research fully entering the genome era. Millions of SNP markers have made genome-wide association study （GWAS） widely used in genetic resources research， making it the most important part of germplasm resources research in the past 10 years. In this golden period， dissecting genetic basis of important agronomic traits through GWAS has become the main content of Cell， Nature and Science and their sub-publishers.In the last century， the establishment and development of crop breeding science promoted establishment of germplasm resource discipline. The development and wide application of genomics in this century has gradually formed a new situation in which research of germplasm resources promotes the development of breeding. Many problems that plague breeders have received important enlightenment or answers through GWAS analysis （such as tomato domestication， breeding history， contradiction between quality and yield， founder genotype， etc.）. Further， the pan-genome research breaks through the limitations of a single reference genome， makes researchers realize the universality of genomic structural variations within a species， and provides a broader perspective for analyzing the formation of landmark cultivars， founder genotypes and the creation new super-cultivars. NAM， MAGIC， and the ideas and practice of constructing new multi-parents genetic mapping populations based on these can make the background level of the mapping population basically reaching the level of the breeding population at the same time， speeding up the fine mapping of agronomically important genes and pre-breeding. This has driven integration and interaction of germplasmics， genomics and breeding. Furthermore， in assistance of speed breeding and gene editing technology， the integration and interaction will surely promote the three disciplines to enter a new time.