Camellia reticulata is a famous ornamental flower in the world， and its flower color is an important ornamental character. The flower color of Camellia reticulata ‘Shizitou’ is deep red， while its bud mutant ‘Damanao’ showing white-red mixed flower is rare with great ornamental value. In this study， both varieties were analyzed at the flower traits by RHSCC colorimetric method， and their metabolites and transcriptional profiles were examined based on transcriptome and metabolome methodologies. Anthocyanin targeted metabolic analysis detected 28 anthocyanin metabolites. There were no different metabolites between the petals of ‘Shizitou’ and ‘Damanao’ in the red region， while the main different metabolites between the white region of the petals of ‘Shizitou’ and ‘Damanao’ were centaurin-3-O-sambudigoside， proanthocyanidin B2， proanthocyanidin B3 and afotoside. The main different metabolites between white and red region of ‘Damanao’ petals were centaurin-3-O-sambuloside， proanthocyanidin B2 and afoside. Transcriptomic KEGG analysis showed that the genes in phenylpropanol biosynthesis and flavonoid biosynthesis pathways were related to the formation of red and white bicolor petals of ‘Damanao’. Plant hormone signal transduction and circadian rhythm-plant pathway were associated with flower color bud change of Camellia reticulata. Transcriptional and metabolic joint analysis identified 17 differentially expressed genes highly related to the color of Camellia reticulata， including 4 CHS， 3 HCT， 2 F3'H， 1 LAR， 5 MYB and 2 bHLH. This study provided a reference for future breeding based on the flower color bud mutation.