By mining QTL significantly associated with zinc content in rice grains， combined with gene function annotation， haplotype and grain relative expression analysis at grain filling stage， candidate genes related to zinc content in rice grains were screened. In this study， 139 core germplasm resources of early japonica rice in Northwest China were used as experimental materials. Combined with 1800920 high-confidence SNPs obtained by resequencing， genome-wide association analysis was performed based on the general linear model （GLM）. The candidate genes in the significant QTL interval were functionally annotated， and the further screened genes were analyzed for haplotypes and relative expression levels at grain filling stage， in order to screen out candidate genes and dominant haplotypes related to grain zinc content. The results showed that there were abundant phenotypic variations in grain zinc content of 139 rice accessions， which were in accordance with normal distribution. Through genome-wide association analysis of zinc content in rice grains， a total of 12 significant SNPs were associated， which were distributed on chromosomes 1， 2， 4， 10 and 11. Combined with the gene function annotation in the candidate interval， it was speculated that OsFRDL2 located in the vesicle may be related to the enrichment of zinc in rice grains. Through the analysis of haplotype and grain relative expression at filling stage， it was found that OsFRDL2 was relatively highly expressed in the dominant haplotype Hap5. Therefore， it is speculated that OsFRDL2 may be related to the enrichment of zinc in rice grains. The results provide a theoretical basis for analyzing the mechanism of zinc enrichment in rice grains and developing molecular markers of zinc-rich rice， and provide genetic resources for cultivating zinc-rich rice.