China is one of the important distribution centers for Begonia in the world, with the karst mountain regions of western Guangxi representing the epicenter, particularly for sect. Coelocentrum. The overall distribution is defined by a myriad of species, diminutive populations, fragmented habitats, and delicate ecosystems. In recent years, the human activities have increasingly interfered with the habitats of wild Begonia populations. In order to further understand the distribution characteristics and population status of Begonia in western Guangxi, wild Begonia resources in Chongzuo, Baise and Hechi in western Guangxi were investigated from 2017 to 2022, involvcluding 66 Begonia species (53 officially published species or subspecies and 13 suspected new species) across nearly 140 wild populations. The habitats and growth conditions of various populations were mainly investigated and recorded while the literature and herbarium specimens were also analyzed. The findings indicate that most wild populations were in good condition of growth and regeneration, however, human activities, especially infrastructure development, tourism expansion, and unregulated harvesting, pose threats to some wild populations of Begonia, pushing a few to the brink of extinction. The resources of Begonia in western Guangxi are extremely rich and include some species yet to be discovered or published., and there are many taxa with high ornamental value and development potential, especially sect. Coelocentrum. Based on the investigation of the distribution and growth of wild Begonia resources in western Guangxi, this study summarized the overall distribution characteristics and diversity of the resources, and put forward suggestions on how to further develop and utilize of these resources while ensuring their protection.