Chrysanthemum （Chrysanthemum morifolium） has important ornamental and economic value. Drought reduces its yield and quality， resulting in great economic losses. It is an important means to solve the above problems to dig out drought resistant genes in chrysanthemum and cultivate drought resistant varieties. MYB transcription factors are involved in plant growth and development and response to abiotic stress. This study involved the heterologous expression of the CmMYB15-like gene from chrysanthemum in Arabidopsis， followed by the observation of phenotypic changes under drought stress. The investigation of drought resistance function of this gene included measurement of relative water content （RWC）， malondialdehyde （MDA） content， soluble sugars （SS）content， superoxide dismutase （SOD） activity， and lignin content. The survival rate， relative water content， superoxide dismutase activity and soluble sugar content of overexpressed CmMYB15-like Arabidopsis thaliana were significantly increased compared with the wild type， while the malondialdehyde content was significantly decreased compared with the wild type. The length of taproot and number of lateral roots were significantly higher than those of wild type. In addition， AtPAL2， AtPAL4， At4CL1 and other lignin synthesis-related genes were significantly up-regulated， and the lignin content was significantly increased.These results indicate that CmMYB15-like is involved in the drought stress response of Arabidopsis thaliana， which provides a theoretical basis for the selection of drought-resistant gene resources and breeding of chrysanthemum cultivars.