Heavy metals， such as cadmium and plumbum， are increasingly contaminating soil. These pollutants not only interfere the plant life cycle but also diminish crop yields and can even lead to plant mortality. Plants have evolved a series of defense mechanisms to mitigate the stress induced by heavy metals. Plant MYB transcription factors play pivotal role as key regulators under stress conditions. They interact with downstream target genes in response to heavy metal stress， thus enhancing tolerance and minimizing damage to plants. To elucidate the molecular mechanisms by which plants cope with heavy metal stress （especially cadmium stress） is a primary goal in plant biotechnology and agricultural breeding.This article reviews several critical aspects， including the identification and characteristics of MYB family members， their functions， the mechanisms of regulating target genes， as well as exploring how MYB modulate target genes to participate in heavy metal stress response through photosynthesis and hormones. Furthermore， we discuss the adaptive mechanism of plants to heavy metal stress， where MYB transcription factors combine with target genes or promoter elements through signaling pathways， including reactive oxygen species homeostasis， abscisic acid signaling， gibberellins signaling， and photosynthesis. These interactions are critical for regulating the uptake， transport and sequestration of heavy metals in plants. Collectively， this review provides a theoretical foundation for the further exploitation and utilization of MYB transcription factors in enhancing plant resilience to heavy metal stress.